A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization
نویسندگان
چکیده
منابع مشابه
Glycoprotein Influences Glycosaminoglycan Utilization
3 4 Laurie A. Silva, Solomiia Khomandiak, Alison W. Ashbrook, Romy Weller, 5 Mark T. Heise, Thomas E. Morrison, and Terence S. Dermody 6 7 Departments of Pediatrics and Pathology, Microbiology, and Immunology, and 8 Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of 9 Medicine, Nashville, Tennessee, USA 10 Departments of Genetics and Microbiology and Immunology and...
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Several rabies virus (RV) vaccine strains containing an aspartic acid (Asp) or glutamic acid (Glu) instead of an arginine (Arg) at position 333 of the RV glycoprotein (G) are apathogenic for immunocompetent mice even after intracranial inoculation. However, we previously showed that the nonpathogenic phenotype of the highly attenuated RV strain SPBNGA, which contains a Glu at position 333 of G,...
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Chikungunya fever is one of the reemerging vector-borne diseases. It has become a major global health problem especially in the developing countries. There are no vaccines or specific antiviral drugs available to date. This study reports small molecule inhibitors of envelope glycoprotein 2 (E2 glycoprotein) which are predicted based on Chikungunya virus-host interactions. E2 glycoprotein of Chi...
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متن کاملAttenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.
Chikungunya virus (CHIKV) is the mosquito-borne alphavirus that is the etiologic agent of massive outbreaks of arthralgic febrile illness that recently affected millions of people in Africa and Asia. The only CHIKV vaccine that has been tested in humans, strain 181/clone 25, is a live-attenuated derivative of Southeast Asian human isolate strain AF15561. The vaccine was immunogenic in phase I a...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X
DOI: 10.1128/jvi.03116-13